Indianapolis, Indiana and Carolina, Puerto Rico

MNA served as the design team leader and worked with the Owner’s process development and construction team to implement a state-of-the-art continuous manufacturing suite at two different sites. The project consisted of designing a suite for the CDC (continuous direct compression) process equipment for OSD (oral solid dosage) products. Integration of the of the entire production process into a seamless and continuous flow was the goal of the project.

The first suite was built in Indianapolis, Indiana and served as the prototype project. The project team started with a blank sheet and developed every aspect of the layout, process flow, structure, and controls. Once the prototype was operational, work began on the second site in Carolina, Puerto Rico. Through a team approach and a focus on continuous improvement, the team was able to provide both the functionality and stability required for the sensitive control metering and measuring devices.

The project was ultimately recognized for its engineering effort by the International Society for Pharmaceutical Engineering in 2017. The project was the overall winner of the prestigious Facility of The Year Award (FOYA).

Design Team:

• MEP Designer: MNA
• Local Permitting: Babilonia Engineering Group
• Architect/Structural Design Partner: TLF, Inc.
• Construction Managers: Davis & Associates/Fluor Daniels Caribbean, Inc.

Key Metrics:

• 23,000-square-foot area | 4,500 square feet each
• 2014–2015 for designing
• 2015–2016 for construction
• Received the 2017 FOYA Overall Winner – ISPE award | Pharmaceutical Engineering Magazine

Noblesville, Indiana

Clean rooms for manufacturing of valves and devices utilized in the semi-conductor manufacturing process. The project was constructed within an existing 35,000-square-foot facility with room classifications ranging from ISO 5 and ISO 7. The project included nine air handlers, chilled glycol system, heated glycol system, and a steam boiler system. Musset Nicholas provided architectural, mechanical, and electrical design and SME oversight for the design build project.

Bloomington, Indiana

MNA provided full design services for a new Formulation Suite which encompasses a Grade C clean room, Grade D corridor and air locks, gowning rooms, equipment room, and mechanical mezzanine.

Systems included:

• HVAC
• Water for injection
• Clean steam
• Clean compressed air
• Nitrogen
• Process waste
• Heating hot water
• Chilled water
• Power
• Lighting
• HVAC controls
• Process controls utility interface
• Power distribution
• Access control

The project was fast tracked as part of Operation Warp Speed for the COVID-19 Vaccine program. From concept to validation, the project was completed in six months.

Durham, North Carolina

New buildout of existing shell space to provide new ISO-8 clean room manufacturing space for micro-electronics. Completed May 2022, this 18,500-square-foot area consists of one large room, a growing room, and utility space. A mechanical mezzanine was incorporated for the support utilities and air handling equipment. A new chiller plant and hot water plant included. Mussett Nicholas provided architectural, me- chanical, and electrical design for the project.

Utility systems included were:

• Solvent exhaust
• Corrosive exhaust
• DI water
• Process waste
• Clean dry air
• Vacuum
• Chilled water
• Heating hot water
• Process chilled water
• Power
• Fire protection
• Controls